Title: autoimmune polyendocrinopathy
Long Title: IUPAC Gold Book - autoimmune polyendocrinopathy
DOI: 10.1351/goldbook.13587
Status: current

Definition
Autoimmune disease affecting multiple endocrine organs.

Notes
1) (i) The autoimmune polyglandular syndrome type 1 is characterized by mucocutaneous candidiasis in association with endocrine manifestation (also called APECED syndrome, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy). (ii) The autoimmune polyglandular syndrome type 2 exhibits any combination of adrenal insufficiency (see Addison disease), diabetes mellitus type 1, lymphocytic thyroiditis (see thyroiditis, autoimmune), hypoparathyroidism, and gonadal failure.
2) In both types, organ-specific autoantibodies against a variety of endocrine glands are detectable.

Related Terms
- Addison disease: https://goldbook.iupac.org/terms/view/12845
- Autoimmune disease: https://goldbook.iupac.org/terms/view/12919
- autoantibodies: https://goldbook.iupac.org/terms/view/12913
- autoimmune: https://goldbook.iupac.org/terms/view/12918
- diabetes mellitus type 1: https://goldbook.iupac.org/terms/view/13092
- thyroiditis: https://goldbook.iupac.org/terms/view/13741

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1231 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13587/html
- json: https://goldbook.iupac.org/terms/view/13587/json
- xml: https://goldbook.iupac.org/terms/view/13587/xml

Citation: Citation: 'autoimmune polyendocrinopathy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13587
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Accessed: 2026-07-01T08:55:46+00:00