Title: progressive systemic sclerosis
Long Title: IUPAC Gold Book - progressive systemic sclerosis
DOI: 10.1351/goldbook.13609
Status: current

Definition
Systemic autoimmune disease marked by formation of hyalinized and thickened collagenous fibrous tissue, with thickening and adhesion of skin to underlying tissues, especially of the hands and face and vascular alterations.

Related Terms
- Systemic autoimmune disease: https://goldbook.iupac.org/terms/view/13709
- scleroderma: https://goldbook.iupac.org/terms/view/13660

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1235 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13609/html
- json: https://goldbook.iupac.org/terms/view/13609/json
- xml: https://goldbook.iupac.org/terms/view/13609/xml

Citation: Citation: 'progressive systemic sclerosis' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13609
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-05-10T05:55:36+00:00