https://doi.org/10.1351/goldbook.13617
Multifunctional enzyme of azurophilic granules of neutrophils and monocytes and the major target of antineutrophil cytoplasmic autoantibodies (ANCA).
Note: PR3 autoantibodies are diagnostic markers for Wegener granulomatosis (WG) and are involved in the pathogenesis of this disease. They are also found in patients with other autoimmune systemic vasculitic diseases.