Title: sarcoidosis
Long Title: IUPAC Gold Book - sarcoidosis
DOI: 10.1351/goldbook.13658
Status: current

Definition
Chronic, progressive, generalized granulomatous reticulosis of unknown etiology, involving almost any organ or tissue, including the skin, lungs, lymph nodes, liver, spleen, eyes, and small bones of the hands and feet. It is characterized histologically by the presence in all affected organs or tissues of noncaseating epithelioid cell tubercles.

Note
There is usually diminished or absent reactivity to tuberculin, and in most active cases, a positive Kveim reaction.

Related Terms
- Kveim reaction: https://goldbook.iupac.org/terms/view/13368
- granulomatous: https://goldbook.iupac.org/terms/view/13185
- tuberculin: https://goldbook.iupac.org/terms/view/13757

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1241 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13658/html
- json: https://goldbook.iupac.org/terms/view/13658/json
- xml: https://goldbook.iupac.org/terms/view/13658/xml

Citation: Citation: 'sarcoidosis' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13658
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Accessed: 2026-05-14T09:50:55+00:00