self-tolerance

https://doi.org/10.1351/goldbook.13669
Specific immunological unresponsiveness to a defined autoantigen.
Notes:
  1. Primary (clonal deletion, anergy, clonal indifference) and secondary or regulatory (interclonal competition, suppression, immune deviation, vetoing, feedback regulation by the idiotypic network) mechanisms are involved in the induction and maintenance of self-tolerance.
  2. Breaking self-tolerance may lead to pathological autoimmunity and development of autoimmune disease.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1243 [Terms] [Paper]
Citation: 'self-tolerance' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13669 RIS BibTex EndNote
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