Title: suppression
Long Title: IUPAC Gold Book - suppression
DOI: 10.1351/goldbook.13701
Status: current

Definition
Dominant immunological tolerance, a phenomenon that plays an active role in regulating T-cell and B-cell responses to both foreign antigens and autoantigens.

Note
The downregulation of responses to autoantigens is a major regulatory mechanism involved in the induction and maintenance of self-tolerance.

Related Terms
- B-cell: https://goldbook.iupac.org/terms/view/12937
- T-cell: https://goldbook.iupac.org/terms/view/13724
- autoantigens: https://goldbook.iupac.org/terms/view/12914
- self-tolerance: https://goldbook.iupac.org/terms/view/13669
- tolerance: https://goldbook.iupac.org/terms/view/13302

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1248 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13701/html
- json: https://goldbook.iupac.org/terms/view/13701/json
- xml: https://goldbook.iupac.org/terms/view/13701/xml

Citation: Citation: 'suppression' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13701
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Accessed: 2026-05-10T04:02:18+00:00