{"term":{"id":"13710","title":"systemic lupus erythematosus","longtitle":"IUPAC Gold Book - systemic lupus erythematosus","doi":"10.1351\/goldbook.13710","code":"13710","status":"current","initialism":"<em>initialism<\/em>: SLE","synonym":"<em>synonyms<\/em>: lupus, lupus erythematosus","definitions":[{"id":1,"text":"Chronic autoimmune disease that is potentially debilitating and sometimes fatal as the immune system attacks the body’s cells and tissues, with inflammation and tissue damage.","notes":{"1":"SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remission. SLE can occur at any age, and is most common in women, particularly of non-European descent.","2":"The disease is very heterogeneous in clinical expression and serological factors. Autoantibodies directed against nuclear components [antinuclear antibodies (ANA)] are typically detected. Anti-dsDNA, anti-Sm, and antiphospholipid antibodies are used as classification criteria."},"links":[{"term":"Autoantibodies","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12913"},{"term":"antinuclear antibodies (ANA)","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12898"},{"term":"autoimmune disease","url":"https:\/\/goldbook.iupac.org\/terms\/view\/12919"},{"term":"immune system","url":"https:\/\/goldbook.iupac.org\/terms\/view\/13271"}],"sources":["PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1249 (https:\/\/doi.org\/10.1351\/PAC-REC-11-06-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/13710\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/13710\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/13710\/plain"},"citation":"Citation: 'systemic lupus erythematosus' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.13710","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-06-28T13:53:37+00:00"}}