Title: tetramer staining
Long Title: IUPAC Gold Book - tetramer staining
DOI: 10.1351/goldbook.13730
Status: current

Definition
Technique used for selective staining of antigen-specific T lymphocytes in vitro or in situ. The antigen is presented to T cells by peptide tetramer constructs of major histocompatibility (MHC) class I molecules. It is also used to isolate antigen-specific T-cell populations for clonal expansion.

Related Terms
- T lymphocytes: https://goldbook.iupac.org/terms/view/13724
- clonal expansion: https://goldbook.iupac.org/terms/view/13014
- major histocompatibility (MHC) class I molecules: https://goldbook.iupac.org/terms/view/13431
- peptide tetramer: https://goldbook.iupac.org/terms/view/13546

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1252 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13730/html
- json: https://goldbook.iupac.org/terms/view/13730/json
- xml: https://goldbook.iupac.org/terms/view/13730/xml

Citation: Citation: 'tetramer staining' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13730
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Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.
Accessed: 2026-05-15T05:04:40+00:00