tumor necrosis factor

initialism: TNF
synonyms: cachectin, cachexin, TNF-α
https://doi.org/10.1351/goldbook.13762
Protein produced and secreted by several of the body’s cell types, including leukocytes.
Notes:
  1. It promotes the destruction of some types of cancer cells and is a cytokine involved in systemic inflammation.
  2. Activation of the \(\ce{TNF\mbox{-}\upalpha}\) receptor may trigger apoptosis through the extrinsic pathway.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1256 [Terms] [Paper]
Citation: 'tumor necrosis factor' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13762 RIS BibTex EndNote
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