Title: unresponsiveness
Long Title: IUPAC Gold Book - unresponsiveness
DOI: 10.1351/goldbook.13768
Status: current

Definition
Inability to respond to an antigenic stimulus.

Note
Unresponsiveness may be specific for a particular antigen (see tolerance), or broadly nonspecific as a result of damage to the entire immune system, for example, after whole-body irradiation.

Related Terms
- antigenic: https://goldbook.iupac.org/terms/view/12885
- immune system: https://goldbook.iupac.org/terms/view/13271
- tolerance: https://goldbook.iupac.org/terms/view/13302

Source
- PAC, 2012, 84, 1113. 'IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)' on page 1257 (https://doi.org/10.1351/PAC-REC-11-06-03)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/13768/html
- json: https://goldbook.iupac.org/terms/view/13768/json
- xml: https://goldbook.iupac.org/terms/view/13768/xml

Citation: Citation: 'unresponsiveness' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13768
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Accessed: 2026-05-14T16:16:44+00:00