{"term":{"id":"14107","title":"allosteric site","longtitle":"IUPAC Gold Book - allosteric site","doi":"10.1351\/goldbook.14107","code":"14107","status":"current","definitions":[{"id":1,"text":"Binding site on a protein, distinct from the site recognized by an endogenous agonist (i.e., the orthosteric site) in the case of a receptor, or substrate in the case of an enzyme, that when occupied by a ligand effects a conformational change in the protein, thus altering its signaling, catalytic properties, or its capability to interact with other macromolecules.","links":[{"term":"orthosteric site","url":"https:\/\/goldbook.iupac.org\/terms\/view\/14173"}],"sources":["PAC, 2011, 83, 1129. 'Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)' on page 1132 (https:\/\/doi.org\/10.1351\/PAC-REC-09-05-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/14107\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/14107\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/14107\/plain"},"citation":"Citation: 'allosteric site' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.14107","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-05-14T20:51:30+00:00"}}