14154 IUPAC Gold Book - label-free detection 10.1351/goldbook.14154 14154 current 1 Direct detection of compound activity on a target without the requirement for a labeled reagent. Use of calorimetry, mass spectrometry, surface plasmon resonance, or nuclear magnetic resonance to measure a signal. PAC, 2011, 83, 1129. 'Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)' on page 1146 (https://doi.org/10.1351/PAC-REC-09-05-03) https://goldbook.iupac.org/terms/view/14154/html https://goldbook.iupac.org/terms/view/14154/json https://goldbook.iupac.org/terms/view/14154/plain Citation: 'label-free detection' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.14154 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-06-27T15:20:51+00:00