{"term":{"id":"14155","title":"lead identification","longtitle":"IUPAC Gold Book - lead identification","doi":"10.1351\/goldbook.14155","code":"14155","status":"current","definitions":[{"id":1,"text":"Process that is targeted toward the generation of at least one compound series that meets the requirements for progression to lead optimization.","notes":{"1":"Typically, it encompasses the steps from the detection of initial activity (via high-throughput screening and other lead-finding activities) through hit confirmation and hit-to-lead activities."},"sources":["PAC, 2011, 83, 1129. 'Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)' on page 1146 (https:\/\/doi.org\/10.1351\/PAC-REC-09-05-03)"]}],"altoutputs":{"html":"https:\/\/goldbook.iupac.org\/terms\/view\/14155\/html","xml":"https:\/\/goldbook.iupac.org\/terms\/view\/14155\/xml","plain":"https:\/\/goldbook.iupac.org\/terms\/view\/14155\/plain"},"citation":"Citation: 'lead identification' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351\/goldbook.14155","license":"The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https:\/\/creativecommons.org\/licenses\/by-sa\/4.0\/) for individual terms.","collection":"If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .","disclaimer":"The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.","accessed":"2026-06-27T15:22:21+00:00"}}