biphasic dose–effect model

https://doi.org/10.1351/goldbook.14505
  1. Model of adverse effect vs. dose relationship that, owing to hormesis, dips down from the control level before increasing with the dose; individuals exposed to low, but nontoxic concentrations are healthier than individuals not exposed to the chemical.
    Note: Biphasic dose–effect curves occur for any nutrient. Hormesis is a phenomenon associated with compounds that have no nutrient properties.
  2. Model of adverse effect vs. dose relationship that changes slope owing to a change in the mechanism of toxic action.
    Note: This may, e.g., be due to saturation of a transport or metabolic system.
Source:
PAC, 2009, 81, 829. (Glossary of terms used in ecotoxicology (IUPAC Recommendations 2009)) on page 853 [Terms] [Paper]
Citation: 'biphasic dose–effect model' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.14505 RIS BibTex EndNote
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