Title: dominant lethal mutation
Long Title: IUPAC Gold Book - dominant lethal mutation
DOI: 10.1351/goldbook.15651
Status: current

Definition
Genetic change occurring in a germ cell that does not cause dysfunction of the gamete but which is lethal to the fertilized egg or developing embryo which develops from it.

Note
Induction of a dominant lethal event after exposure to a chemical substance (dominant lethal test) indicates that the substance has affected germinal tissue of the test species.

Source
- PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1208 (https://doi.org/10.1351/pac200779071153)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/15651/html
- json: https://goldbook.iupac.org/terms/view/15651/json
- xml: https://goldbook.iupac.org/terms/view/15651/xml

Citation: Citation: 'dominant lethal mutation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.15651
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Accessed: 2026-05-15T00:20:02+00:00