<?xml version="1.0" encoding="UTF-8"?>
<term>
  <id>16054</id>
  <title>reverse mutation</title>
  <longtitle>IUPAC Gold Book - reverse mutation</longtitle>
  <doi>10.1351/goldbook.16054</doi>
  <code>16054</code>
  <status>current</status>
  <synonym><em>synonym</em>: back mutation</synonym>
  <definitions>
    <item>
      <id>1</id>
      <text>Mutation in a mutant allele which makes it capable of producing the nonmutant phenotype; this may result from restoration of the original DNA sequence of the gene or from production of a new DNA sequence which has the same effect.</text>
      <sources>
        <item>PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1302 (https://doi.org/10.1351/pac200779071153)</item>
      </sources>
    </item>
  </definitions>
  <altoutputs>
    <html>https://goldbook.iupac.org/terms/view/16054/html</html>
    <json>https://goldbook.iupac.org/terms/view/16054/json</json>
    <plain>https://goldbook.iupac.org/terms/view/16054/plain</plain>
  </altoutputs>
  <citation>Citation: 'reverse mutation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.16054</citation>
  <license>The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms.</license>
  <collection>If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org .</collection>
  <disclaimer>The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using.</disclaimer>
  <accessed>2026-07-26T11:11:12+00:00</accessed>
</term>
