Title: tumor suppressor gene
Long Title: IUPAC Gold Book - tumor suppressor gene
DOI: 10.1351/goldbook.16174
Status: current

Definition
Gene that serves to protect cells from entering a cancerous state.

Note
According to Knudson’s "two-hit" hypothesis, both alleles of a particular tumor suppressor gene must acquire a mutation before the cell will enter a transformed state.

Source
- PAC, 2007, 79, 1153. 'Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)' on page 1330 (https://doi.org/10.1351/pac200779071153)

Other Outputs
- html: https://goldbook.iupac.org/terms/view/16174/html
- json: https://goldbook.iupac.org/terms/view/16174/json
- xml: https://goldbook.iupac.org/terms/view/16174/xml

Citation: Citation: 'tumor suppressor gene' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.16174
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Accessed: 2026-07-27T00:34:40+00:00