00241 IUPAC Gold Book - allostery 10.1351/goldbook.A00241 A00241 current 1 A phenomenon whereby the conformation of an enzyme or other protein is altered by combination, at a site other than the substrate-binding site, with a small molecule, referred to as an effector, which results in either increased or decreased activity by the enzyme. binding site https://goldbook.iupac.org/terms/view/B00649 conformation https://goldbook.iupac.org/terms/view/C01258 effector https://goldbook.iupac.org/terms/view/E01901 enzyme https://goldbook.iupac.org/terms/view/E02159 PAC, 1994, 66, 2587. 'Glossary of bioanalytical nomenclature - Part 1: General terminology, body fluids, enzymology, immunology (IUPAC Recommendations 1994)' on page 2593 (https://doi.org/10.1351/pac199466122587) https://goldbook.iupac.org/terms/view/A00241/html https://goldbook.iupac.org/terms/view/A00241/json https://goldbook.iupac.org/terms/view/A00241/plain Citation: 'allostery' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.A00241 The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. 2026-05-14T19:46:28+00:00