Title: replacement operation Long Title: IUPAC Gold Book - replacement operation DOI: 10.1351/goldbook.R05298 Status: current Definition The exchange of one group of atoms or a single non-hydrogen atom for another. Source - Blue Book Guide, p. 23 (https://doi.org/10.1351/pac199971071327) Other Outputs - html: https://goldbook.iupac.org/terms/view/R05298/html - json: https://goldbook.iupac.org/terms/view/R05298/json - xml: https://goldbook.iupac.org/terms/view/R05298/xml Citation: Citation: 'replacement operation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.R05298 License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International (https://creativecommons.org/licenses/by-sa/4.0/) for individual terms. Collection: If you are interested in licensing the Gold Book for commercial use, please contact the IUPAC Executive Director at executivedirector@iupac.org . Disclaimer: The International Union of Pure and Applied Chemistry (IUPAC) is continuously reviewing and, where needed, updating terms in the Compendium of Chemical Terminology (the IUPAC Gold Book). Users of these terms are encouraged to include the version of a term with its use and to check regularly for updates to term definitions that you are using. Accessed: 2026-06-28T10:10:30+00:00