Western Pacific amyotrophic lateral sclerosis and parkinsonism–dementia complex

initialism: ALS-PDC
https://doi.org/10.1351/goldbook.12179
Neurodegenerative disease observed in the islands of Guam, Indonesia, Japan and Papua New Guinea, showing combinations of characteristics of amyotrophic lateral sclerosis, atypical parkinsonism with dementia, or dementia alone that may present sequentially during life.
Notes:
  1. Neurotoxins of the cycad plant, such as β-N-methylamino-L-alanine (L-BMAA) produced by symbiotic cyanobacteria, and methylazoxymethanol (MAM), are suspected causative agents.
  2. Polyproteinopathy, notably tauopathy, is a common causative feature underlying the different clinical manifestations.
Source:
PAC, 2015, 87, 841. (IUPAC Glossary of terms used in neurotoxicology (IUPAC Recommendations 2015)) on page 916 [Terms] [Paper]
Citation: 'Western Pacific amyotrophic lateral sclerosis and parkinsonism–dementia complex' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12179 RIS BibTex EndNote
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