allelic exclusion

https://doi.org/10.1351/goldbook.12856
Phenomenon whereby, following successful rearrangement of one allele of an antigen receptor gene, rearrangement of the other parental allele is suppressed, thereby ensuring each lymphocyte expresses only a single specificity of antigen receptor.
Note: This does not occur for \(\upalpha\) chains in T lymphocytes.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1120 [Terms] [Paper]
Citation: 'allelic exclusion' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12856 RIS BibTex EndNote
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