CD4+/CD25+ T cell

https://doi.org/10.1351/goldbook.12974
Subtype of CD4+ regulatory T cell (Treg) with potential role in the regulation of immune homeostasis.
Notes:
  1. These cells seem to be important in preventing the development of autoimmune diseases (depletion leads to the spontaneous development of various autoimmune diseases in genetically susceptible animals; transfer prevents the development of organ-specific autoimmunity).
  2. Activated T cells may also have this phenotype. Treg cells may be further distinguished by positivity for a protein marker Foxp3.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1138 [Terms] [Paper]
Citation: 'CD4+/CD25+ T cell' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12974 RIS BibTex EndNote
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