https://doi.org/10.1351/goldbook.13185
Mass or nodule of granulation tissue, with actively growing fibroblasts and capillary buds, characterized by the presence of aggregates of modified macrophages resembling epithelial cells (epithelioid histiocytes), and lymphocytes, surrounded by a rim of giant multinucleate cells, either of the Langerhans or foreign body type.
Note: Granuloma is due to a chronic inflammatory process associated with infectious disease, such as tuberculosis, syphilis, sarcoidosis, leprosy, lymphogranuloma, etc., or with invasion by a foreign body.