https://doi.org/10.1351/goldbook.13281
Inability to produce a normal repertoire of antibodies or immunologically sensitized T lymphocytes, especially in response to specific antigens.
Notes:
- Defects in one or more components of the immune system result in the inability to eliminate or neutralize antigens.
- Congenital or primary immunodeficiencies are genetic or due to developmental disorders, such as congenital thymic aplasia (see also thymic atrophy).
- Acquired or secondary immunodeficiencies develop as a consequence of malnutrition, malignancies, immunosuppressive compounds, radiation or infection of immunocompetent T lymphocytes with human immunodeficiency virus (HIV).
- Defects in natural immunity may also result in immunodeficiency.