NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3

initialisms: NALP3, NLRP3
synonym: cryopyrin
https://doi.org/10.1351/goldbook.13492
NOD-like receptor (NLR), found in certain inflammasomes, that binds to aggregated proteins and the peptides that compose them. Its activation leads to the generation of inflammatory cytokines, such as interleukin (IL)-1, and neurotoxic factors.
Note: Mutations in NALP3 are responsible for the autoinflammatory diseases familial cold autoinflammatory syndrome, Muckle–Wells syndrome and neonatal onset multisystem inflammatory disease.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1218 [Terms] [Paper]
Citation: 'NACHT domain-, leucine-rich repeat (LRR)-, and pyrin (N-terminal homology) domain (PYD)-containing protein 3' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13492 RIS BibTex EndNote
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