nucleotide-binding oligomerization domain-containing protein-like receptor

initialism: NLR
synonym: NOD-like receptor protein (NLRP)
https://doi.org/10.1351/goldbook.13520
Cytosolic protein that contains a central nucleotide-binding oligomerization domain, an N-terminal effector-binding domain and C-terminal leucine-rich repeats (LRRs).
Notes:
  1. NOD-like receptors have been implicated as mediators of protective immune responses against intracellular pathogens.
  2. Genetic associations of polymorphisms in NOD-like receptor genes with complex chronic inflammatory barrier diseases, such as Crohn disease and asthma, and with rare auto-inflammatory syndromes including familial cold urticaria, Muckle–Wells syndrome and Blau syndrome have been described.
See also: NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 (NALP3, NLRP3)
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1222 [Terms] [Paper]
Citation: 'nucleotide-binding oligomerization domain-containing protein-like receptor' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13520 RIS BibTex EndNote
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