autoimmune polyendocrinopathy

synonyms: APECED syndrome, autoimmune polyendocrinopathy
https://doi.org/10.1351/goldbook.13587
Autoimmune disease affecting multiple endocrine organs.
Notes:
  1. (i) The autoimmune polyglandular syndrome type 1 is characterized by mucocutaneous candidiasis in association with endocrine manifestation (also called APECED syndrome, autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy). (ii) The autoimmune polyglandular syndrome type 2 exhibits any combination of adrenal insufficiency (see Addison disease), diabetes mellitus type 1, lymphocytic thyroiditis (see thyroiditis, autoimmune), hypoparathyroidism, and gonadal failure.
  2. In both types, organ-specific autoantibodies against a variety of endocrine glands are detectable.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1231 [Terms] [Paper]
Citation: 'autoimmune polyendocrinopathy' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13587 RIS BibTex EndNote
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