lead identification

https://doi.org/10.1351/goldbook.14155
Process that is targeted toward the generation of at least one compound series that meets the requirements for progression to lead optimization.
Note: Typically, it encompasses the steps from the detection of initial activity (via high-throughput screening and other lead-finding activities) through hit confirmation and hit-to-lead activities.
Source:
PAC, 2011, 83, 1129. (Glossary of terms used in biomolecular screening (IUPAC Recommendations 2011)) on page 1146 [Terms] [Paper]
Citation: 'lead identification' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.14155 RIS BibTex EndNote
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