tumor suppressor gene

https://doi.org/10.1351/goldbook.16174
Gene that serves to protect cells from entering a cancerous state.
Note: According to Knudson’s "two-hit" hypothesis, both alleles of a particular tumor suppressor gene must acquire a mutation before the cell will enter a transformed state.
Source:
PAC, 2007, 79, 1153. (Glossary of terms used in toxicology, 2nd edition (IUPAC Recommendations 2007)) on page 1330 [Terms] [Paper]
Citation: 'tumor suppressor gene' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.16174 RIS BibTex EndNote
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