ABL oncogene

synonym: BCR-ABL
https://doi.org/10.1351/goldbook.12827
Gene resulting from a chromosomal translocation (9;22) that fuses sequences from the BCR (breakpoint cluster region) gene with the ABL gene.
Notes:
  1. This translocation creates the Philadelphia chromosome, found in most human patients with chronic myelogenous leukemia (CML).
  2. The fusion protein encoded by BCR-ABL possesses unregulated tyrosine kinase activity.
  3. The term ABL derives from the Abelson murine leukemia virus, from which the gene was first isolated.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1115 [Terms] [Paper]
Citation: 'ABL oncogene' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12827 RIS BibTex EndNote
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