B7 molecule

https://doi.org/10.1351/goldbook.12933
Co-stimulatory molecule on the surface of T-cell-activating antigen-presenting cells (APCs), allowing full activation of T cells that are bound to major histocompatibility complex (MHC)-peptide complexes.
Note: Whereas binding of B7 molecules to CD28 is stimulatory, binding to cytotoxic T-lymphocyte antigen-4 (CTLA-4) decreases T-cell activity and participates in tolerance.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1132 [Terms] [Paper]
Citation: 'B7 molecule' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.12933 RIS BibTex EndNote
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