co-stimulation

https://doi.org/10.1351/goldbook.13051
Delivery of a second signal, in addition to that of antigen binding or antigen presentation, that is required for lymphocyte proliferation.
Notes:
  1. Co-stimulatory signals are delivered to T cells by the co-stimulatory molecules, B7.1 and B7.2, related molecules (see B7 molecule) that are expressed on the surface of the antigen-presenting cell (APC), and which bind the T-cell surface molecule CD28.
  2. B cells may receive co-stimulatory signals from common pathogen components such as lipopolysaccharide (LPS), from complement fragments, or from CD40 ligand (CD40L) expressed on the surface of an activated antigen-specific helper T lymphocyte (Th).
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1150 [Terms] [Paper]
Citation: 'co-stimulation' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13051 RIS BibTex EndNote
Div. VIITextXMLJSON