F(ab')2 fragment

https://doi.org/10.1351/goldbook.13136
Bivalent antigen-binding fragment obtained following pepsin digestion of immunoglobulin. Consists of both light chains and the N-terminal part of both heavy chains linked by disulfide bonds.
Note: Because it lacks the Fc fragment it does not bind the Fc-receptor, e.g., in flow cytometry.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1164 [Terms] [Paper]
Citation: 'F(ab')2 fragment' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13136 RIS BibTex EndNote
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