progressive systemic sclerosis

https://doi.org/10.1351/goldbook.13609
Systemic autoimmune disease marked by formation of hyalinized and thickened collagenous fibrous tissue, with thickening and adhesion of skin to underlying tissues, especially of the hands and face and vascular alterations.
See also: scleroderma
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1235 [Terms] [Paper]