https://doi.org/10.1351/goldbook.13632
Intermittent bilateral attacks of vasospasm and ischemia of the fingers or toes and sometimes of the ears and nose, marked by a severe pallor and often accompanied by paresthesia and pain.
Notes:
- It is brought on characteristically by cold or emotional stimuli and relieved by heat, and may be due to an underlying disease or anatomic abnormality.
- The phenomenon is more common in women than men and occurs in most patients with progressive systemic sclerosis (SSc), mixed connective tissue disease (MCTD), and polymyositis/scleroderma overlap syndrome.
- When the condition is idiopathic or primary, it is termed Raynaud disease.