V(D)J recombination

https://doi.org/10.1351/goldbook.13770
Mechanism for generating antigen-specific receptors of T cells and B cells; it involves the joining of V, D, and J gene segments, mediated by the enzyme complex V(D)J recombinase, and products of the recombination-activating genes.
Notes:
  1. The conventional syntax V(D)J indicates that V and J genes code the light chain and all three genes code the heavy chain, the processes being VJ and VDJ recombination, respectively.
  2. Recombination occurs only once in a cell’s lifetime.
See also: somatic recombination
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1258 [Terms] [Paper]
Citation: 'V(D)J recombination' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13770 RIS BibTex EndNote
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