joining gene

synonym: J gene
https://doi.org/10.1351/goldbook.13354
Gene coding for a joining segment that connects variable (V) regions and constant (C) regions of immunoglobulin (Ig) or T-cell receptor (TCR) chains that, upon gene rearrangement, encodes part of the third hypervariable region of the antigen receptors.
Note: In Ig light chains and TCR, a variable (V) gene segment rearranges to a joining (J) gene segment; in Ig heavy chains and TCR, a diversity (D) gene segment rearranges to a joining (J) gene segment.
See also: V(D)J recombination
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1197 [Terms] [Paper]
Citation: 'joining gene' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13354 RIS BibTex EndNote
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