variable region

synonyms: V domain, V region, variable domain
https://doi.org/10.1351/goldbook.13773
N-terminal portion of an immunoglobulin (Ig) or T-cell receptor (TCR) that contains the antigen-binding region of the molecule. V regions are formed by the recombination of V(D) and J gene segments.
Note: The V region consists of two V domains, \({\rm{V}}_{\rm{L}}\) and \({\rm{V}}_{\rm{H}}\).
See also: somatic recombination, V(D)J-recombination
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1258 [Terms] [Paper]
Citation: 'variable region' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13773 RIS BibTex EndNote
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