isotype switch

https://doi.org/10.1351/goldbook.13349
Process by which a B cell switches from making antibody of one isotype to another without altering the specificity of the antibody, producing an isotype with the same variable (V) regions but a different heavy chain constant (C) region.
Source:
PAC, 2012, 84, 1113. (IUPAC glossary of terms used in immunotoxicology (IUPAC Recommendations 2012)) on page 1197 [Terms] [Paper]
Citation: 'isotype switch' in IUPAC Compendium of Chemical Terminology, 5th ed. International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. https://doi.org/10.1351/goldbook.13349 RIS BibTex EndNote
Div. VIITextXMLJSON